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Dear Dr. Hunter,

you were very helpful in getting a CellML model by Dr. Friel here at
CWRU straighened out. The particular model had been originally
translated into CellML by the Auckland group and was in the depository.
You initiated the events that lead Peter Villiger at your place to
modify the model so that it would run properly. I do not know whether
you heard about the end result, but it was very successful and we thank
you for it.

My purpose today is to inquire whether there still is a group at
Bioengineering at Auckland that translates mathematical models into
CellML. A post-doc in my lab developed a model for sodium bicarbonate
reabsorption by proximal tubule cells 10 years ago (Orosz DE, Hopfer U.
Pathophysiological consequences of changes in the coupling ratio of
Na,K-ATPase for renal sodium reabsorption and its implications for
hypertension. Hypertension. 1996 Feb;27(2):219-27). The modeling was
based on a C-based meta-language called SCoP (developed by Mailen
Cootsey, http://www.simresinc.com). The interest to translate the model
into CellML comes from international collaborations and a need to
interprete the functional significance of biochemical changes (levels of
transporters) in terms of overall transepithelial absorption rates,
which are related to sodium homeostasis and hypertension. The advantage
of CellML would be the transportability of the model between different labs.

If you could tell me whether there still is a group and interest in
CellML at Auckland and, if so, could you put me in contact with them.

Sincerely,

--
Ulrich Hopfer, M.D., Ph.D.
Professor of Physiology & Biophysics and Medicine
Case Western Reserve University School of Medicine
tel.: 216-368-2878
fax: 216-368-3952
E-mail: ulrich.hopfer at case.edu



--
Ulrich Hopfer, M.D., Ph.D.
Professor of Physiology & Biophysics and Medicine
Case Western Reserve University School of Medicine
tel.: 216-368-2878
fax: 216-368-3952
E-mail: ulrich.hopfer at case.edu

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• [cellml-discussion] [Fwd: [Fwd: inquiry]], Peter Villiger, 11/20/2006

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