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Hi David,

thanks for your kind reply. The link for OpenRave is the correct one. The
SOFA link is http://www.sofa-framework.org/ . What SOFA does well is provide
a suitable architecture for interactive medical simulation at the organ
level. Where CellML will complement it is modeling processes at the cell and
tissue levels, thereby complementing what SOFA has already in the development
of multi-scale interactive medical simulation, especially if it is possible
to distribute the computation, either over several cores, or over several
GPUs.

I don't have a mathematical expression for this change in porosity of the
BBB. You could say that I'm still dipping my toe in the pool, in terms of my
immersion in computational biology. I imagine that if there is a model for
diffusion of molecules accross a tissue layer, that would be a place to
start, but ideally, I would like something that is well adapted to the
blood-brain barrier itself. I guess Google is my friend, and I can report
back if I find such an expression.

Cheers,

Michel

The basic idea that I have is to pursue the development of
Michel Audette, Ph.D.
Assistant Professor,
Department of Modeling, Simulation and Visualization Engineering,
Old Dominion University,
Norfolk, VA.
________________________________________
From: cellml-discussion-bounces at cellml.org [cellml-discussion-bounces at
cellml.org] On Behalf Of David Nickerson [david.nickerson at gmail.com]
Sent: Wednesday, August 15, 2012 7:23 PM
To: CellML Discussion List
Subject: Re: [cellml-discussion] naive questions about modeling blood-brain
barrier and its disruption

Hi Michel,

Thanks for the enquiry. Just because this is a completely new type of
application, to me at least, could you please provide a couple of
pointers to some more information. A quick google shows
http://openrave.org/ - is that the simulation tool that you are
referring to? But I can't find anything obvious for SOFA... And do you
know of any introductory papers or other documents which might provide
a bit of detail as to the mathematics you would like to encode in
CellML for this particular application.

Cheers,
David.

On Thu, Aug 16, 2012 at 7:07 AM, Audette, Michel A. <maudette at odu.edu>
wrote:
> Dear CellML developers and users,
>
> I would like to write a white paper to the US Dept of Defense that
> describes how CellML might be combined with SOFA and OpenRave-based robotic
> therapy simulation, where in particular I would like to leverage your
> toolkit to model an increase of porosity of the blood-brain barrier, which
> can be triggered by ultrasonic energy delivery, as well as the uptake of a
> drug.
>
> My knowledge of CellML is almost nil, and I'm open to any suggestion.
>
> Best wishes,
>
> Michel
>
> Michel Audette, Ph.D.
> Assistant Professor,
> Department of Modeling, Simulation and Visualization Engineering,
> Old Dominion University,
> Norfolk, VA.
> _______________________________________________
> cellml-discussion mailing list
> cellml-discussion at cellml.org
> http://lists.cellml.org/mailman/listinfo/cellml-discussion
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• [cellml-discussion] naive questions about modeling blood-brain barrier and its disruption, Audette, Michel A., 08/16/2012
  • [cellml-discussion] naive questions about modeling blood-brain barrier and its disruption, David Nickerson, 08/16/2012
    • [cellml-discussion] naive questions about modeling blood-brain barrier and its disruption, Audette, Michel A., 08/16/2012

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