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Hi David,

That's the information that I really wanted in the first place. Thank you
for your answer. However, I have several questions after I read all of the
XML contents you gave:
1. (*S1S2-restitution.xml*) When is exactly S2Time and S2Interval used?
Since the main condition only using stimulusSwitch as the conditional
parameter.
2. (*switch from a periodic stimulus protocol to a single pulse*) I think I
got a little bit confused about this sentence. I've already checked the
SINGLE PULSE i_stim and it looks similar to the conditional statement of
i_stim value (for instance, *ten_Tusscher_panfilov_2006 *model). So, is
that really periodic to single?
3. Can I say S2 Interval as the BCL version of S2 protocol?

Maybe that's the only questions I want to know. Anyway, thanks for the
useful reference, David. Really appreciate your help.

Aroli Marcellinus

*Kumoh Institute of Technology**Computational Medicine Laboratory*
61 Daehak-ro (Sinpyeong-dong), Gumi, Gyeongbuk
+82 10 9724 3957
KTalk ID: vondarkness

On Fri, Apr 13, 2018 at 2:08 AM, David Nickerson
<david.nickerson AT gmail.com>
wrote:

> Hi Aroli,
>
> You can see another example in here for a pure CellML S1S2 protocol
> definition: https://models.physiomeproject.org/w/andre/
> nickerson-2008/file/d6328d18c94e9dad70f4d0e4b250e8
> 9429773b62/cellml/protocols;
> in particular https://models.physiomeproject.org/w/andre/
> nickerson-2008/rawfile/d6328d18c94e9dad70f4d0e4b250e8
> 9429773b62/cellml/protocols/S1S2-restitution.xml
> defines the switch from a periodic stimulus protocol to a single pulse
> at the appropriate interval. Note these files won't simulate in
> OpenCOR on their own, but maybe give an idea how to implement your own
> S1S2 in CellML if you are after a pure CellML solution.
>
> The protocol language used in the WebLab is a lot more capable in
> terms of specifying arbitrary stimulus protocols, as well as being
> able to pull out restitution/APD properties - which can't be done in
> pure CellML.
>
> Cheers,
> Andre.
>
> On 12 April 2018 at 03:47, Cooper, Jonathan
> <j.p.cooper AT ucl.ac.uk>
> wrote:
> > Hi Aroli,
> >
> >
> >
> > I’m not sure I quite understand your question. The plot you link shows
> both
> > the AP arising from the last S1 stimulus and the AP from the S2
> stimulus. In
> > the version of S1-S2 restitution there, we do many S1 paces to get the
> model
> > to quasi-steady-state. However, it’s possible to write a different
> version
> > of the protocol if you want it to do something different. There’s a link
> to
> > the protocol at the top of the results page, so you can see how it’s
> > implemented.
> >
> >
> >
> > Best wishes,
> >
> > Jonathan
> >
> >
> >
> > From:
> > <cellml-discussion-request AT lists.cellml.org>
> > on behalf of Aroli
> > Marcellinus
> > <aroli.marcellinus AT gmail.com>
> > Reply-To:
> > "cellml-discussion AT cellml.org"
> >
> > <cellml-discussion AT cellml.org>
> > Date: Thursday, 12 April 2018 at 05:05
> > To:
> > "cellml-discussion AT cellml.org"
> >
> > <cellml-discussion AT cellml.org>
> >
> >
> > Subject: Re: [cellml-discussion] S1S2 Stimulus Protocol in CellML cell
> model
> >
> >
> >
> > Hi Cooper,
> >
> > Thank you for the recommendation. I have looked at the simulator, but can
> > you explain to me about the simulator? Since I just only found S2 result,
> > but no S1. How can I simulate both S1 and S2 simulation on this platform?
> >
> >
> > Aroli Marcellinus
> > Kumoh Institute of Technology
> > Computational Medicine Laboratory
> > 61 Daehak-ro (Sinpyeong-dong), Gumi, Gyeongbuk
> > +82 10 9724 3957
> > KTalk ID: vondarkness
> >
> >
> >
> > On Wed, Apr 11, 2018 at 6:41 PM, Cooper, Jonathan
> > <j.p.cooper AT ucl.ac.uk>
> > wrote:
> >
> > Hi Aroli,
> >
> >
> >
> > You might also want to look at our Web Lab, which has a S1-S2 restitution
> > protocol - https://chaste.cs.ox.ac.uk/WebLab/db/protocols/7 - run on a
> range
> > of models, including post-processing of the raw results. We can give you
> an
> > account if you want to add your own CellML files to the collection.
> >
> >
> >
> > Best wishes,
> >
> > Jonathan
> >
> >
> >
> > From:
> > <cellml-discussion-request AT lists.cellml.org>
> > on behalf of Alan
> Garny
> > <a.garny AT auckland.ac.nz>
> > Reply-To:
> > "cellml-discussion AT cellml.org"
> >
> > <cellml-discussion AT cellml.org>
> > Date: Wednesday, 11 April 2018 at 02:15
> > To: cellml-discussion Mailing List
> > <cellml-discussion AT lists.cellml.org>
> > Subject: Re: [cellml-discussion] S1S2 Stimulus Protocol in CellML cell
> model
> >
> >
> >
> > Hi Aroli,
> >
> >
> >
> > Yes, an S1S2 stimulus protocol can be applied to a CellML file. Just
> replace
> > the existing stimulus protocol (if any) in the CellML file with your S1S2
> > stimulus protocol.
> >
> >
> >
> > Alan
> >
> >
> >
> > From:
> > <cellml-discussion-request AT lists.cellml.org>
> > on behalf of Aroli
> > Marcellinus
> > <aroli.marcellinus AT gmail.com>
> > Reply-To: cellml-discussion Mailing List
> > <cellml-discussion AT lists.cellml.org>
> > Date: Wednesday, 11 April 2018 at 1:03 PM
> > To: cellml-discussion Mailing List
> > <cellml-discussion AT lists.cellml.org>
> > Subject: [cellml-discussion] S1S2 Stimulus Protocol in CellML cell model
> >
> >
> >
> > Hello everyone,
> >
> > I just want to know if the S1S2 stimulus can be applied to CellML cell
> > models. Is there any reference or method to replace the common stimulus
> > protocol into S1S2 stimulus protocol?
> >
> > Thank you
> >
> >
> >
> >
> > Aroli Marcellinus
> > Kumoh Institute of Technology
> > Computational Medicine Laboratory
> > 61 Daehak-ro (Sinpyeong-dong), Gumi, Gyeongbuk
> > +82 10 9724 3957
> > KTalk ID: vondarkness
> >
> >
>
>
>
> --
>
>
> David Nickerson
> about.me/david.nickerson
>

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• [cellml-discussion] S1S2 Stimulus Protocol in CellML cell model, Aroli Marcellinus, 04/11/2018
  • Re: [cellml-discussion] S1S2 Stimulus Protocol in CellML cell model, Alan Garny, 04/11/2018
    • Re: [cellml-discussion] S1S2 Stimulus Protocol in CellML cell model, Cooper, Jonathan, 04/11/2018
      • Re: [cellml-discussion] S1S2 Stimulus Protocol in CellML cell model, Aroli Marcellinus, 04/12/2018
        • Re: [cellml-discussion] S1S2 Stimulus Protocol in CellML cell model, Cooper, Jonathan, 04/12/2018
          • Re: [cellml-discussion] S1S2 Stimulus Protocol in CellML cell model, David Nickerson, 04/13/2018
            • Re: [cellml-discussion] S1S2 Stimulus Protocol in CellML cell model, Aroli Marcellinus, 04/13/2018
              • Re: [cellml-discussion] S1S2 Stimulus Protocol in CellML cell model, Aroli Marcellinus, 04/13/2018

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