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Ahh, it's alright, David. I just finished thinking about the questions and
I already understand what you want to say. Anyway, your reference helps me
so much to study S1S2. Thank you very much.

Aroli Marcellinus

*Kumoh Institute of Technology**Computational Medicine Laboratory*
61 Daehak-ro (Sinpyeong-dong), Gumi, Gyeongbuk
+82 10 9724 3957
KTalk ID: vondarkness

On Fri, Apr 13, 2018 at 2:50 PM, Aroli Marcellinus <
aroli.marcellinus AT gmail.com>
wrote:

> Hi David,
>
> That's the information that I really wanted in the first place. Thank you
> for your answer. However, I have several questions after I read all of the
> XML contents you gave:
> 1. (*S1S2-restitution.xml*) When is exactly S2Time and S2Interval used?
> Since the main condition only using stimulusSwitch as the conditional
> parameter.
> 2. (*switch from a periodic stimulus protocol to a single pulse*) I think
> I got a little bit confused about this sentence. I've already checked the
> SINGLE PULSE i_stim and it looks similar to the conditional statement of
> i_stim value (for instance, *ten_Tusscher_panfilov_2006 *model). So, is
> that really periodic to single?
> 3. Can I say S2 Interval as the BCL version of S2 protocol?
>
> Maybe that's the only questions I want to know. Anyway, thanks for the
> useful reference, David. Really appreciate your help.
>
> Aroli Marcellinus
>
> *Kumoh Institute of Technology**Computational Medicine Laboratory*
> 61 Daehak-ro (Sinpyeong-dong), Gumi, Gyeongbuk
> +82 10 9724 3957
> KTalk ID: vondarkness
>
> On Fri, Apr 13, 2018 at 2:08 AM, David Nickerson <
> david.nickerson AT gmail.com>
> wrote:
>
>> Hi Aroli,
>>
>> You can see another example in here for a pure CellML S1S2 protocol
>> definition: https://models.physiomeproject.org/w/andre/nickerson-2008/
>> file/d6328d18c94e9dad70f4d0e4b250e89429773b62/cellml/protocols;
>> in particular https://models.physiomeproject.org/w/andre/nickerson-2008/
>> rawfile/d6328d18c94e9dad70f4d0e4b250e89429773b62/cellml/
>> protocols/S1S2-restitution.xml
>> defines the switch from a periodic stimulus protocol to a single pulse
>> at the appropriate interval. Note these files won't simulate in
>> OpenCOR on their own, but maybe give an idea how to implement your own
>> S1S2 in CellML if you are after a pure CellML solution.
>>
>> The protocol language used in the WebLab is a lot more capable in
>> terms of specifying arbitrary stimulus protocols, as well as being
>> able to pull out restitution/APD properties - which can't be done in
>> pure CellML.
>>
>> Cheers,
>> Andre.
>>
>> On 12 April 2018 at 03:47, Cooper, Jonathan
>> <j.p.cooper AT ucl.ac.uk>
>> wrote:
>> > Hi Aroli,
>> >
>> >
>> >
>> > I’m not sure I quite understand your question. The plot you link shows
>> both
>> > the AP arising from the last S1 stimulus and the AP from the S2
>> stimulus. In
>> > the version of S1-S2 restitution there, we do many S1 paces to get the
>> model
>> > to quasi-steady-state. However, it’s possible to write a different
>> version
>> > of the protocol if you want it to do something different. There’s a
>> link to
>> > the protocol at the top of the results page, so you can see how it’s
>> > implemented.
>> >
>> >
>> >
>> > Best wishes,
>> >
>> > Jonathan
>> >
>> >
>> >
>> > From:
>> > <cellml-discussion-request AT lists.cellml.org>
>> > on behalf of Aroli
>> > Marcellinus
>> > <aroli.marcellinus AT gmail.com>
>> > Reply-To:
>> > "cellml-discussion AT cellml.org"
>> >
>> > <cellml-discussion AT cellml.org>
>> > Date: Thursday, 12 April 2018 at 05:05
>> > To:
>> > "cellml-discussion AT cellml.org"
>> >
>> > <cellml-discussion AT cellml.org>
>> >
>> >
>> > Subject: Re: [cellml-discussion] S1S2 Stimulus Protocol in CellML cell
>> model
>> >
>> >
>> >
>> > Hi Cooper,
>> >
>> > Thank you for the recommendation. I have looked at the simulator, but
>> can
>> > you explain to me about the simulator? Since I just only found S2
>> result,
>> > but no S1. How can I simulate both S1 and S2 simulation on this
>> platform?
>> >
>> >
>> > Aroli Marcellinus
>> > Kumoh Institute of Technology
>> > Computational Medicine Laboratory
>> > 61 Daehak-ro (Sinpyeong-dong), Gumi, Gyeongbuk
>> > +82 10 9724 3957
>> > KTalk ID: vondarkness
>> >
>> >
>> >
>> > On Wed, Apr 11, 2018 at 6:41 PM, Cooper, Jonathan
>> > <j.p.cooper AT ucl.ac.uk
>> >
>> > wrote:
>> >
>> > Hi Aroli,
>> >
>> >
>> >
>> > You might also want to look at our Web Lab, which has a S1-S2
>> restitution
>> > protocol - https://chaste.cs.ox.ac.uk/WebLab/db/protocols/7 - run on a
>> range
>> > of models, including post-processing of the raw results. We can give
>> you an
>> > account if you want to add your own CellML files to the collection.
>> >
>> >
>> >
>> > Best wishes,
>> >
>> > Jonathan
>> >
>> >
>> >
>> > From:
>> > <cellml-discussion-request AT lists.cellml.org>
>> > on behalf of Alan
>> Garny
>> > <a.garny AT auckland.ac.nz>
>> > Reply-To:
>> > "cellml-discussion AT cellml.org"
>> >
>> > <cellml-discussion AT cellml.org>
>> > Date: Wednesday, 11 April 2018 at 02:15
>> > To: cellml-discussion Mailing List
>> > <cellml-discussion AT lists.cellml.org>
>> > Subject: Re: [cellml-discussion] S1S2 Stimulus Protocol in CellML cell
>> model
>> >
>> >
>> >
>> > Hi Aroli,
>> >
>> >
>> >
>> > Yes, an S1S2 stimulus protocol can be applied to a CellML file. Just
>> replace
>> > the existing stimulus protocol (if any) in the CellML file with your
>> S1S2
>> > stimulus protocol.
>> >
>> >
>> >
>> > Alan
>> >
>> >
>> >
>> > From:
>> > <cellml-discussion-request AT lists.cellml.org>
>> > on behalf of Aroli
>> > Marcellinus
>> > <aroli.marcellinus AT gmail.com>
>> > Reply-To: cellml-discussion Mailing List
>> > <cellml-discussion AT lists.cellml.org>
>> > Date: Wednesday, 11 April 2018 at 1:03 PM
>> > To: cellml-discussion Mailing List
>> > <cellml-discussion AT lists.cellml.org>
>> > Subject: [cellml-discussion] S1S2 Stimulus Protocol in CellML cell model
>> >
>> >
>> >
>> > Hello everyone,
>> >
>> > I just want to know if the S1S2 stimulus can be applied to CellML cell
>> > models. Is there any reference or method to replace the common stimulus
>> > protocol into S1S2 stimulus protocol?
>> >
>> > Thank you
>> >
>> >
>> >
>> >
>> > Aroli Marcellinus
>> > Kumoh Institute of Technology
>> > Computational Medicine Laboratory
>> > 61 Daehak-ro (Sinpyeong-dong), Gumi, Gyeongbuk
>> > +82 10 9724 3957
>> > KTalk ID: vondarkness
>> >
>> >
>>
>>
>>
>> --
>>
>>
>> David Nickerson
>> about.me/david.nickerson
>>
>
>

---

• [cellml-discussion] S1S2 Stimulus Protocol in CellML cell model, Aroli Marcellinus, 04/11/2018
  • Re: [cellml-discussion] S1S2 Stimulus Protocol in CellML cell model, Alan Garny, 04/11/2018
    • Re: [cellml-discussion] S1S2 Stimulus Protocol in CellML cell model, Cooper, Jonathan, 04/11/2018
      • Re: [cellml-discussion] S1S2 Stimulus Protocol in CellML cell model, Aroli Marcellinus, 04/12/2018
        • Re: [cellml-discussion] S1S2 Stimulus Protocol in CellML cell model, Cooper, Jonathan, 04/12/2018
          • Re: [cellml-discussion] S1S2 Stimulus Protocol in CellML cell model, David Nickerson, 04/13/2018
            • Re: [cellml-discussion] S1S2 Stimulus Protocol in CellML cell model, Aroli Marcellinus, 04/13/2018
              • Re: [cellml-discussion] S1S2 Stimulus Protocol in CellML cell model, Aroli Marcellinus, 04/13/2018

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