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[cellml-discussion] model variants(?): e.g. where multiple cell types are described by the same model in different files


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  • From: j.lawson at auckland.ac.nz (James Lawson)
  • Subject: [cellml-discussion] model variants(?): e.g. where multiple cell types are described by the same model in different files
  • Date: Thu, 12 Apr 2007 11:30:52 +1200

Addendum:

The model in the repository describes the apex cells only.

James Lawson wrote:
> Hi folks,
>
> I'm just fishing for some comments on how to handle cases where there
> are models which describe, for example, the properties of multiple cell
> types. Bondarenko et al. 2004 is a good example of this:
>
> "In the Bondarenko et al. 2004 publication described here, the authors
> develop a computer model of the mouse ventricular action potential (see
> below). The model includes parameters for both the apex and the septum
> regions of the heart (the apex parameters have been substituted into the
> CellML version of the model described in ), and this helps to illustrate
> how there are regional differences in myocyte repolarisation in the
> mouse heart."
>
> Penny Noble has just sent me a zip file containing the latest versions
> of all the models she has curated for COR. I'm currently in the process
> of comparing these versions to the latest versions we have on the
> repository. In some cases, she has provided several variants of the same
> model which describe different cell types, as above.
>
> Firstly, are these true 'variants'? If so, then the matter is relatively
> simple. Unfortunately, if one goes through the repository list, variants
> simply come up as a duplication of the model listing, with no
> information concerning what the variant represents. This is something I
> imagine will be fixed in time, but is presently rather frustrating
> considering the issue at hand.
>
> Does anyone have any comments on this? Should I simply put the files up
> as different variants, with a note in the documentation?
>
> Thanks,
> James Lawson
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